Epigenetics, Aging & Skin Inflammation
SEOUL, KOREAWe connect clinical questions, single-cell analysis and bioinformatics with functional experiments to understand skin aging, inflammation and skin–brain interaction.
Public skin single-cell data and tissue immunofluorescence provide complementary evidence for OX40⁺ regulatory T cells in atopic dermatitis. Shown: the complete original Figure 6.
We connect patient observations with cellular maps and computational analysis, then test mechanistic hypotheses through functional experiments.
Connect clinical phenotypes with PBMC single-cell RNA-seq, and cross-check observations using flow cytometry and public skin datasets.
Infer cell states, regulatory programs and potential interactions; integrate transcriptomes across conditions to prioritize candidates.
Test mechanistic hypotheses through gene perturbation and receptor antagonism, connected to cellular, behavioral and electrophysiological readouts.
From biology to medical devices.
One starting point: skin.
How do time and environment change the skin? How do skin-derived signals connect to the brain? How does inflammation become disease? These questions also guide our work in medical devices and precise outcome assessment.
01 / TIMEWe investigate how time and environmental exposure reshape gene regulation and the extracellular matrix in skin.
Questions & publications
02 / CONNECTIONWe explore how environmental exposure and peripheral signals connect the skin to brain function and systemic physiology.
Questions & publications
03 / DISEASEWe connect clinical questions in atopic dermatitis and related inflammatory skin diseases with immune-cell states and molecular mechanisms.
Questions & publications
04 / TECHNOLOGYWe study skin changes after energy-based treatments through clinical assessment and quantitative imaging, with the PI’s Dongguk University MBA background in medical device innovation management adding a perspective on clinical needs and technology use.
Questions & publicationsSelected publications and Research Stories feature papers in which Dong Hun Lee is a first or corresponding author, including shared first and corresponding authorship.
39-parameter CyTOF, public single-cell datasets, suppression assays and skin-tissue validation investigate OX40⁺ regulatory T cells.
Transcriptomes from senescence models and HDAC4 perturbation identified DDIT4 for follow-up gene perturbation experiments.
Beyond the skinAnimal studies examined how chronic UV exposure relates to dopamine signaling, memory and synaptic function.
Article titles link to the original publications. Animal-model findings do not establish clinical effects in humans.
Physician-scientist.
Connecting clinical questions with biological mechanisms.
Seoul National University
Biomedical Research Institute, Seoul National University Hospital
Experimental Dermatology
High-dimensional immune profiling research published in Allergology International.
Research on the miR-382-5p–SLC26A3 axis published in Experimental Dermatology.
Serving as Editor-in-Chief from January 2026.
Skin aging and epigenomics, inflammatory skin disease, skin–brain interaction, medical devices and EBD. Get in touch—even at the earliest idea stage.
We welcome prospective students and interns, and collaboration proposals from researchers, clinicians and industry partners.
